Chester's Nick Meyer was 14-for-24 passing for 342 yards with three touchdowns and Calvin Clendenin had nine receptions for 245 yards with two scores in the Yellow Jackets win over Edwards County.
Anna-Jonesboro's Jayce Turner rushed for 174 yards with three touchdowns and Bryce Osman added 90 yards rushing with four scores in the Wildcats win over Benton.
Fairfield's Lance Jolly had 21 carries for 117 yards with two touchdowns to lead the Mules to an undefeated regular season with a win over S-V-W-W.
Marion's Caden Hilliard ran 10 times for 129 yards with three touchdowns to lead the Wildcats past Mattoon.
Du Quoin's Hank Stewart was 11-for-19 passing for 167 yards, added 66 rushing yards and accounted for three touchdowns in the Indians win over Murphysboro.
Carbondale's Jakeba Burleigh completed 15-of-23 passes for 194 yards with two touchdowns and Jaden Bradley caught five passes for 65 yards with two scores in the Terriers win over Harrisburg.
Nashville quarterback Cameron Parker found Dalton Novak in the right corner of the end zone with 14 seconds left in the fourth quarter for the game winning score in the Hornets win over West Frankfort.